A broadly cross-reactive i-body to AMA1 potently inhibits blood and liver stages of Plasmodium parasites

M Foley, D Angage, R Anders, J Chmielewski… - 2023 - researchsquare.com
… showed that WD34 inhibits merozoite invasion into RBCs by … antimalarial antibody with
high invasion inhibitory activity. … biopanning strategy of phage-displayed i-body library against …

[PDF][PDF] Research Article Bioinformatic Identification of Peptidomimetic-Based Inhibitors against Plasmodium falciparum Antigen AMA1

A Alam - academia.edu
… also inhibited merozoite invasion of human red blood cells (RBCs) … “Phage-displayed
peptides bind to the malarial protein apical membrane antigen-1 and inhibit the merozoite invasion

Identification of an immunogenic broadly inhibitory surface epitope of the Plasmodium vivax Duffy binding protein ligand domain

MT George, JL Schloegel, FB Ntumngia, SJ Barnes… - Msphere, 2019 - Am Soc Microbiol
… , especially a vaccine to control and prevent vivax malaria. … Biopanning of DBPII phage
displayed fragment library for … block DBP-erythrocyte binding or inhibition of merozoite invasion of …

[HTML][HTML] Eimeria tenella: specific EtAMA1-binding peptides inhibit sporozoite entry into host cells

D Ma, Y Huang, C Ma, L Zhang, J Wang, D Wang, J Li… - Poultry Science, 2019 - Elsevier
… and animal diseases including malaria and toxoplasmosis. … the invasion of parasites into
host erythrocytes by inhibiting the … The findings of the present study indicated that an apical

[PDF][PDF] Small Molecule Inhibitors of AMA1/RON2 Interaction as New Antimalarial Agents

M Akter - 2020 - scholar.archive.org
Apical membrane antigen 1 (AMA1) and rhoptry neck protein … in merozoites prevent parasites
from invading the erythrocyte.… of merozoites at the start of invasion,17 erythrocyte binding,…

Peptides Mimicking Epitopes on Malarial Antigens from Random Peptide Libraries Displayed on Phage

C Adda - 2024 - opal.latrobe.edu.au
… utility of phage-displayed random peptide libraries in malaria … to the malarial life cycle, such
as erythrocyte invasion. Whilst … can inhibit the invasion of merozoites into the host erythrocyte

[HTML][HTML] Specific EtMIC3-binding peptides inhibit Eimeria tenella sporozoites entry into host cells

W Chen, C Ma, G Li, Z Jia, X Yang, X Pan, D Ma - Veterinary Research, 2021 - Springer
… , damaged intestinal villi, numerous red cells, and infiltration of … stages including sporozoites,
merozoites, and gametocytes. … Apical membrane antigen 1 (AMA1) is one of the microneme …

Applications of the phage display technology in molecular biology, biotechnology and medicine

K Pierzynowska, J Morcinek-Orłowska… - Critical Reviews in …, 2023 - Taylor & Francis
… With the help of phage-displayed peptide libraries, two peptide … hepatocytes or for erythrocyte
invasion (merozoite surface proteins 1, 2 and … Some of these reports concern malaria. Two …

Exploring shark VNAR antibody against infectious diseases using phage display technology

HT Lim, BH Kok, CY Leow, CH Leow - Fish & shellfish immunology, 2023 - Elsevier
… The application of phage-displayed shark VNAR in antibody … most prevalent and lethal
among the malaria parasites [104]. … of red blood cells [105]. Nuttall et al. [14] have isolated 12Y-2 …

Current Development in Peptide Surrogates Synthesis and Their Biological Applications

A Kalmouch, AM Naglah… - Egyptian Journal of …, 2023 - ejchem.journals.ekb.eg
… of the parasite life-cycle, for example, invasion of host erythrocytes [125, 126]. Significant
hurdles that … bind to the malarial protein apical membrane antigen-1 and inhibit the merozoite